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6th Canadian Symposium on Hepatitis C Virus: Delivering a cure for hepatitis C infection—What are the remaining gaps? Sarwat Khan, Annie Bernier, Dustin Dapp, Emmanuel Fortier, Mel Krajden, Alexandra King, Jason Grebely, Selena M Sagan, Curtis L Cooper, Angela M Crawley, on behalf of the Canadian Network on Hepatitis C (CanHepC). CanLivJ 2018; 1(2) pp. 94–105.


Saeed S, Strumpf EC, Moodie EE, Young J, Nitulescu R, Cox J, Wong A, Walmsely S, Cooper C, Vachon ML, Martel-Laferriere V, Hull M, Conway B, Klein MB; Canadian Co-Infection Cohort Study. Disparities in direct acting antivirals uptake in HIV-hepatitis C co-infected populations in Canada. J Int AIDS Soc. 2017 Nov;20(3). 

MacParland SA, Tsoi KM, Ouyang B, Ma XZ, Manuel J, Fawaz A, Ostrowski MA, Alman BA, Zilman A, Chan WC, McGilvray ID. Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood. ACS Nano. 2017 Mar 28;11(3):2428-2443. 

Colpitts CC and Baumert TF. SMAD about hepatitis C virus cell entry and liver disease. Gastroenterology. 2017 Jan; 152(1):21-23.

Colpitts CC and Baumert TF. Claudins in viral infection: from entry to spread. Pflugers Arch. 2017 Jan;469(1):27-34

Abdel-Hakeem MS, Boisvert M, Bruneau J, Soudeyns H, Shoukry NH. Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance. PLoS Pathog. 2017 Feb 1;13(2):e1006191. 

Ablenas CJ, Liu HW, Shkriabai N, Kvaratskhelia M, Cosa G, Götte M. Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate. ACS Infect Dis. 2017 Jan 13;3(1):99-109. 


Saeed S, Strumpf EC, Walmsley SL, Rollet-Kurhajec K, Pick N, Martel-Laferrière V, Hull M, Gill MJ, Cox J, Cooper C, Klein MB; Canadian Co-Infection Cohort Study. How Generalizable Are the Results From Trials of Direct Antiviral Agents to People Coinfected With HIV/HCV in the Real World? Clin Infect Dis. 2016 Apr 1;62(7):919-26.

Strmiskova M, Desrochers GF, Shaw TA, Powdrill MH, Lafreniere MA, Pezacki JP. Chemical Methods for Probing Virus-Host Proteomic Interactions. ACS Infect Dis. 2016 Nov 11;2(11):773-786.

Lafreniere MA, Powdrill MH, Singaravelu R, Pezacki JP. 6-Hydroxydopamine Inhibits the Hepatitis C Virus through Alkylation of Host and Viral Proteins and the Induction of Oxidative Stress. ACS Infect Dis. 2016 Nov 11;2(11):863-871.

Powdrill MH, Desrochers GF, Singaravelu R, Pezacki JP. The role of microRNAs in metabolic interactions between viruses and their hosts. Curr Opin Virol. 2016 Aug;19:71-6. 

Tsoi, K.M., MacParland, S.A., Spetzler, V.N., Ma, X.Z., Fadel, S.M., Sykes, E.A., Conneely, J.B., Alman, B., Selzner, M., Ostrowski, M.A., Adeyi, O.A., Zilman, A., McGilvray, I.D. and Chan, W.C.W. The mechanism of nanomaterial uptake by the liver. Nat Mater. 2016 Nov; 15(11): 1212–1221.

MacParland SA, Fadel SM, Mihajlovic V, Fawaz A, Kim C, Rahman AK, Liu J, Kaul R, Kovacs C, Grebely J, Dore GJ, Wong DK, Ostrowski MA. HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection. PLoS One. 2016 Apr 28;11(4):e0154433.

MacParland SA, Ma XZ, Chen L, Khattar R, Cherepanov V, Selzner M, Feld JJ, Selzner N, McGilvray ID. Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression. J Virol. 2016 May 27;90(12):5549-60.

Colpitts CC and Baumert TF. Cell surface glycans as viral entry factors and antiviral targets. Recent Advances in Biotechnology. 2016; 3:39-59. Bentham Science

Verrier ER, Colpitts CC, Bach C, Heydmann L, Zona L, Xiao F, Thumann C, Crouchet E, Gaudin R, Sureau C, Cosset FL, McKeating JA, Pessaux P, Hoshida Y, Schuster C, Zeisel MB and Baumert TF.  Solute carrier NTCP regulates innate antiviral immune responses targeting hepatitis C virus infection of hepatocytes. Cell Reports. 2016 Oct; 17:1357-1368.

Boisvert M, Zhang W, Elrod EJ, Bernard NF, Villeneuve JP, Bruneau J, Marcotrigiano J, Shoukry NH, Grakoui A. Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus-Specific Memory B Cells. J Immunol. 2016 Dec 15;197(12):4848-4858.

Boisvert M, Shoukry NH. Type III Interferons in Hepatitis C Virus Infection. Front Immunol. 2016 Dec 23;7:628.

Kofahi HM, Taylor NG, Hirasawa K, Grant MD, Russell RS. Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells. Sci Rep. 2016 Dec 15;6:37433. 

Murira A, Lamarre A. Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection. Front Immunol. 2016 Dec 19;7:609. 

Marshall AD, Saeed S, Barrett L, Cooper CL, Treloar C, Bruneau J, Feld JJ, Gallagher L, Klein MB, Krajden M, Shoukry NH, Taylor LE, Grebely J; the Canadian Network on Hepatitis C (CanHepC). Restrictions for reimbursement of direct-acting antiviral treatment for hepatitis C virus infection in Canada: a descriptive study. CMAJ OPEN October 14, 2016 vol. 4no. 4 E605-E614. 

van Buuren N, Fradette L, Grebely J, King A, Krajden M, MacParland S, Marshall A, Saeed S, Wilson J, Klein MB, and Sagan SM. The 5th Canadian Symposium on Hepatitis C Virus: We’re Not Done Yet: Remaining Challenges in Hepatitis C. Can J Gastroenterol, vol. 2016:7603526. Epub 2016 Oct 24.

Sagan SM, Dupont B, Grebely J, Krajden M, MacParland SA, Raven JF, Saeed S, Feld JJ, Tyrrell LD, Wilson JA. Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan. Can J Gastroenterol, Vol 2016 (2016), Article ID 5743521.


MacParland SA, Corkum CP, Burgess C, Karwowska S, Kroll W, Michalak TI. Differential expression of interferon alpha inducible genes in peripheral blood mononuclear cells from patients chronically infected with hepatitis C virus and healthy donors. Int Immunopharmacol. 2015 Apr;25(2):545-52.

MacParland SA, Chen AY, Corkum CP, Pham TN, Michalak TI. Patient-derived hepatitis C virus inhibits CD4⁺ but not CD8⁺ T lymphocyte proliferation in primary T cells. Virol J. 2015 Jun 19;12:93.

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Cunningham EB, Applegate TL, Lloyd AR, Dore GJ, Grebely J. Mixed HCV infection and reinfection in people who inject drugs--impact on therapy. Nat Rev Gastroenterol Hepatol. 2015 Apr;12(4):218-30.

Moqueet N, Infante-Rivard C, Platt RW, Young J, Cooper C, et al. Favourable IFNL3 genotypes are associated with spontaneous clearance and are differentially distributed in Aboriginals in Canadian HIV-hepatitis C co-infected individuals. Int J Mol Sci. 2015 Mar 20;16(3):6496-512.

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Burles K, van Buuren N, Barry M. Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB. Virology. 2014 Nov;468-470:351-62.

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Nasheri N, McKay CS, Fulton K, Twine S, Powdrill MH, et al. Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions. Chembiochem. 2014 Oct 13;15(15):2195-200.

Artenie AA, Bruneau J, Lévesque A, Wansuanganyi JM. Role of primary care providers in hepatitis C prevention and care: one step away from evidence-based practice. Can Fam Physician. 2014 Oct;60(10):881-2, e468-70.

Abdel-Hakeem MS, Bédard N, Murphy D, Bruneau J, Shoukry NH. Signatures of protective memory immune responses during hepatitis C virus reinfection. Gastroenterology. 2014 Oct;147(4):870-881.e8.

MacParland SA, Bilodeau M, Grebely J, Bruneau J, Cooper C, et al. The 3rd Canadian Symposium on Hepatitis C Virus: expanding care in the interferon-free era. Can J Gastroenterol Hepatol. 2014 Oct;28(9):481-7.

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Atoom AM, Taylor NG, Russell RS. The elusive function of the hepatitis C virus p7 protein. Virology. 2014 Aug;462-463:377-87.

Singaravelu R, Delcorde J, Lyn RK, Steenbergen RH, Jones DM, et al. Investigating the antiviral role of cell death-inducing DFF45-like effector B in HCV replication. FEBS J. 2014 Aug;281(16):3751-65.

Sherratt AR, Nasheri N, McKay CS, O'Hara S, Hunt A, et al. A new chemical probe for phosphatidylinositol kinase activity. Chembiochem. 2014 Jun 16;15(9):1253-6.

Karam P, Powdrill MH, Liu HW, Vasquez C, Mah W, et al. Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA. J Biol Chem. 2014 May 16;289(20):14399-411.

Lyn RK, Singaravelu R, Kargman S, O'Hara S, Chan H, et al. Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes. Sci Rep. 2014 Apr 1;4:4549

Holder KA, Russell RS, Grant MD. Natural killer cell function and dysfunction in hepatitis C virus infection. Biomed Res Int. 2014;2014:903764.

Bamvita JM, Roy E, Zang G, Jutras-Aswad D, Artenie AA, et al. Portraying persons who inject drugs recently infected with hepatitis C accessing antiviral treatment: a cluster analysis. Hepat Res Treat. 2014;2014:631481. [PubMed] Abdel-Hakeem MS, Shoukry NH. Protective immunity against hepatitis C: many shades of gray. Front Immunol. 2014;5:274.

Abdel-Hakeem MS, Shoukry NH. Protective immunity against hepatitis C: many shades of gray. Front Immunol. 2014 Jun 16;5:274.

Singaravelu R, Chen R, Lyn RK, Jones DM, O'Hara S, et al. Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis. Hepatology. 2014 Jan;59(1):98-108.


Steenbergen RH, Joyce MA, Thomas BS, Jones D, Law J, et al. Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers. Hepatology. 2013 Dec;58(6):1907-17.

Grebely J, Bilodeau M, Feld JJ, Bruneau J, Fischer B, et al. The Second Canadian Symposium on hepatitis C virus: a call to action. Can J Gastroenterol. 2013 Nov;27(11):627-32

Holder KA, Stapleton SN, Gallant ME, Russell RS, Grant MD. Hepatitis C virus-infected cells downregulate NKp30 and inhibit ex vivo NK cell functions. J Immunol. 2013 Sep 15;191(6):3308-18.

Thibault PA, Wilson JA. Targeting miRNAs to treat Hepatitis C Virus infections and liver pathology: Inhibiting the virus and altering the host. Pharmacol Res. 2013 Sep; 75:48-59. PMID: 23541631.

Atoom AM, Jones DM, Russell RS. Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production. Virus Res. 2013 Sep;176(1-2):199-210.

Sagan SM, Sarnow P, Wilson JA. Modulation of GB virus B RNA abundance by microRNA-122: dependence on and escape from microRNA-122 restriction. J Virol. 2013 Jul;87(13):7338-47.

Pelletier S, Bédard N, Said E, Ancuta P, Bruneau J, et al. Sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C. J Virol. 2013 Jun;87(12):6769-81.

Deans GD, Raffa JD, Lai C, Fischer B, Krajden M, et al. Mortality in a large community-based cohort of inner-city residents in Vancouver, Canada. CMAJ Open. 2013 May; 1(2):E68-76.

Nasheri N, Joyce M, Rouleau Y, Yang P, Yao S, et al. Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication. Chem Biol. 2013 Apr 18;20(4):570-82.

Thibault PA, Huys A, Dhillon P, Wilson JA. MicroRNA-122-dependent and -independent replication of Hepatitis C Virus in Hep3B human hepatoma cells. Virology. 2013 Feb 5;436(1):179-90.

Law JL, Chen C, Wong J, Hockman D, Santer DM, et al. A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans. PLoS One. 2013;8(3):e59776.

Huys A, Thibault PA, Wilson JA. Modulation of hepatitis C virus RNA accumulation and translation by DDX6 and miR-122 are mediated by separate mechanisms. PLoS One. 2013;8(6):e67437.

Mazumder N, Lyn RK, Singaravelu R, Ridsdale A, Moffatt DJ, et al. Fluorescence lifetime imaging of alterations to cellular metabolism by domain 2 of the hepatitis C virus core protein. PLoS One. 2013;8(6):e66738.

Sarhan MA, Chen AY, Michalak TI. Differential expression of candidate virus receptors in human T lymphocytes prone or resistant to infection with patient-derived hepatitis C virus. PLoS One. 2013;8(4):e62159

Nasheri N, Pezacki JP, Sagan SM. Design and screening of siRNAs against highly structured RNA targets. Methods Mol Biol. 2013;942:69-86.

Weaver A, Menard D, Cabrera C, Taylor A. Embodying the moral code: Thirty years of final girls in slasher films. Psychology of Popular Media Culture. 2013.


Machlin ES, Sarnow P, Sagan SM. Combating hepatitis C virus by targeting microRNA-122 using locked nucleic acids. Curr Gene Ther. 2012 Aug;12(4):301-6.

Singaravelu R, Nasheri N, Sherratt A, Pezacki JP. Systems biology methods help develop a better understanding of hepatitis C virus-induced liver injury. Hepatology. 2012 Jul;56(1):1-4.

Sarhan MA, Pham TN, Chen AY, Michalak TI. Hepatitis C virus infection of human T lymphocytes is mediated by CD5. J Virol. 2012 Apr;86(7):3723-35.

Blais DR, Nasheri N, McKay CS, Legault MC, Pezacki JP. Activity-based protein profiling of host-virus interactions. Trends Biotechnol. 2012 Feb;30(2):89-99.

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Kneteman NM, Asthana S, Lewis J, Dibben C, Douglas D, et al. Impact of calcineurin inhibitors with or without interferon on hepatitis C virus titers in a chimeric mouse model of hepatitis C virus infection. Liver Transpl. 2012 Jan;18(1):38-44.

Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, et al. Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection. PLoS One. 2012;7(7):e40146.

Cabrera C, & Menard AD. She exploded into a million pieces: A multi-method examination of orgasm descriptions in contemporary romance novels. Sexuality and Culture, 2012,16,4.

Zachariades F & Cabrera C. The duty to warn revisited: Contemporary issues in the North American context. Journal of Ethics in Mental Health, 2012, 7,1. Zachariades F & Cabrera C. The duty to warn revisited: Contemporary issues in the North American context. Journal of Ethics in Mental Health, 2012, 7,1.

Zhang C, Huys A, Thibault PA, Wilson JA. Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance. Virology. 2012 Nov 25;433(2):479-88.

Sarhan MA, Chen AY, Russell RS, Michalak TI. Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes. J Gen Virol. 2012 Nov;93(Pt 11):2399-407.

John-Baptiste A, Yeung MW, Leung V, van der Velde G, Krahn M. Cost effectiveness of hepatitis C-related interventions targeting substance users and other high-risk groups: a systematic review. Pharmacoeconomics. 2012 Nov 1;30(11):1015-34.

Pattullo V, Thein HH, Heathcote EJ, Guindi M. Combining semiquantitative measures of fibrosis and qualitative features of parenchymal remodelling to identify fibrosis regression in hepatitis C: a multiple biopsy study. Histopathology. 2012 Sep;61(3):473-87.


Powdrill MH, Tchesnokov EP, Kozak RA, Russell RS, Martin R, et al. Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20509-13.

Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, et al. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7094-8

Jones DM, Atoom AM, Zhang X, Kottilil S, Russell RS. A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus. J Virol. 2011 Dec;85(23):12351-61

Shoukry NH, Pelletier S, Chang KM. A view to natural killer cells in hepatitis C. Gastroenterology. 2011 Oct;141(4):1144-8.

Cheng J, Danielson DC, Nasheri N, Singaravelu R, Pezacki JP. Enhanced specificity of the viral suppressor of RNA silencing protein p19 toward sequestering of human microRNA-122. Biochemistry. 2011 Sep 13;50(36):7745-55.

Berke JM, Vijgen L, Lachau-Durand S, Powdrill MH, Rawe S, et al. Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother. 2011 Aug;55(8):3812-20.

Nasheri N, Cheng J, Singaravelu R, Wu P, McDermott MT, et al. An enzyme-linked assay for the rapid quantification of microRNAs based on the viral suppressor of RNA silencing protein p19. Anal Biochem. 2011 May 15;412(2):165-72.

Lin LT, Chen TY, Chung CY, Noyce RS, Grindley TB, et al. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread. J Virol. 2011 May;85(9):4386-98.

Matthews GV, Pham ST, Hellard M, Grebely J, Zhang L, et al. Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C. Clin Infect Dis. 2011 Mar 15;52(6):803-11.

Pezacki JP, Blake JA, Danielson DC, Kennedy DC, Lyn RK, et al. Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat Chem Biol. 2011 Mar;7(3):137-45.

Machlin ES, Sarnow P, Sagan SM. Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3193-8

Nasheri N, Singaravelu R, Goodmurphy M, Lyn RK, Pezacki JP. Competing roles of microRNA-122 recognition elements in hepatitis C virus RNA. Virology. 2011 Feb 20;410(2):336-44.

Grebely J, Raffa JD, Lai C, Kerr T, Fischer B, et al. Impact of hepatitis C virus infection on all-cause and liver-related mortality in a large community-based cohort of inner city residents. J Viral Hepat. 2011 Jan;18(1):32-41.

Vali B, Tohn R, Cohen MJ, Sakhdari A, Sheth PM, et al. Characterization of cross-reactive CD8+ T-cell recognition of HLA-A2-restricted HIV-Gag (SLYNTVATL) and HCV-NS5b (ALYDVVSKL) epitopes in individuals infected with human immunodeficiency and hepatitis C viruses. J Virol. 2011 Jan;85(1):254-63

Menard, A.D. & Cabrera, C. Whatever the approach, Tab B still fits into slot A: Twenty years of sex scripts in romance novels. Sexuality and Culture, 2011, 15, 1. Menard, A.D. & Cabrera, C. Whatever the approach, Tab B still fits into slot A: Twenty years of sex scripts in romance novels. Sexuality and Culture, 2011, 15, 1.

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Dore GJ, Hellard M, Matthews GV, Grebely J, Haber PS, et al. Effective treatment of injecting drug users with recently acquired hepatitis C virus infection. Gastroenterology. 2010 Jan;138(1):123-35.e1-2.

Liao PC, Ng LT, Lin LT, Richardson CD, Wang GH, et al. Resveratrol arrests cell cycle and induces apoptosis in human hepatocellular carcinoma Huh-7 cells. J Med Food. 2010 Dec;13(6):1415-23.

Grebely J, Matthews GV, Petoumenos K, Dore GJ. Spontaneous clearance and the beneficial impact of treatment on clearance during recent hepatitis C virus infection. J Viral Hepat. 2010 Dec;17(12):896.

Ma XZ, Bartczak A, Zhang J, Khattar R, Chen L, et al. Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome. J Virol. 2010 Dec;84(23):12419-28.

Pelletier S, Drouin C, Bédard N, Khakoo SI, Bruneau J, et al. Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses. J Hepatol. 2010 Nov;53(5):805-16.

Powdrill MH, Bernatchez JA, Götte M. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses. 2010 Oct;2(10):2169-95.

Grebely J, Petoumenos K, Hellard M, Matthews GV, Suppiah V, et al. Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology. 2010 Oct;52(4):1216-24.

Steenbergen RH, Joyce MA, Lund G, Lewis J, Chen R, et al. Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success. Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G844-54

Abdel-Hakeem MS, Bédard N, Badr G, Ostrowski M, Sékaly RP, et al. Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus. J Virol. 2010 Oct;84(19):10429-35.

Vivithanaporn P, Maingat F, Lin LT, Na H, Richardson CD, et al. Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity. PLoS One. 2010 Sep 21;5(9):e12856.

Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, et al. HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur J Immunol. 2010 Sep;40(9):2493-505.

Gujar SA, Jenkins AK, Macparland SA, Michalak TI. Pre-acute hepadnaviral infection is associated with activation-induced apoptotic death of lymphocytes in the woodchuck (Marmota monax) model of hepatitis B. Dev Comp Immunol. 2010 Sep;34(9):999-1008.

Lin LT, Noyce RS, Pham TN, Wilson JA, Sisson GR, et al. Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122. J Virol. 2010 Sep;84(18):9170-80.

Zhao L, Shields J, Tyrrell DL. Functional changes, increased apoptosis, and diminished nuclear factor-kappaB activity of myeloid dendritic cells during chronic hepatitis C infection. Hum Immunol. 2010 Aug;71(8):751-62.

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Lin LT, Dawson PW, Richardson CD. Viral interactions with macroautophagy: a double-edged sword. Virology. 2010 Jun 20;402(1):1-10.

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Sagan SM, Sarnow P. Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7625-6.

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