2016

Marshall AD, Saeed S, Barrett L, Cooper CL, Treloar C, Bruneau J, Feld JJ, Gallagher L, Klein MB, Krajden M, Shoukry NH, Taylor LE, Grebely J; the Canadian Network on Hepatitis C (CanHepC). Restrictions for reimbursement of direct-acting antiviral treatment for hepatitis C virus infection in Canada: a descriptive study. CMAJ OPEN October 14, 2016 vol. 4no. 4 E605-E614. 

van Buuren N, Fradette L, Grebely J, King A, Krajden M, MacParland S, Marshall A, Saeed S, Wilson J, Klein MB, and Sagan SM. The 5th Canadian Symposium on Hepatitis C Virus: We’re Not Done Yet: Remaining Challenges in Hepatitis C. Can J Gastroenterol, vol. 2016. In press.

Sagan SM, Dupont B, Grebely J, Krajden M, MacParland SA, Raven JF, Saeed S, Feld JJ, Tyrrell LD, Wilson JA. Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan. Can J Gastroenterol, Vol 2016 (2016), Article ID 5743521.

2015

Singaravelu R, O'Hara S, Jones DM, Chen R, Taylor NG, et al. MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat Chem Biol. 2015 Dec;11(12):988-93.

Fortier E, Alavi M, Micallef M, Dunlop AJ, Balcomb AC, et al. The effect of social functioning and living arrangement on treatment intent, specialist assessment and treatment uptake for hepatitis C virus infection among people with a history of injecting drug use: The ETHOS study. Int J Drug Policy. 2015 Nov;26(11):1094-102.

Marshall AD, Micallef M, Erratt A, Telenta J, Treloar C, et al. Liver disease knowledge and acceptability of non-invasive liver fibrosis assessment among people who inject drugs in the drug and alcohol setting: The LiveRLife Study. Int J Drug Policy. 2015 Oct;26(10):984-91.

Artenie AA, Jutras-Aswad D, Roy É, Zang G, Bamvita JM, et al. Visits to primary care physicians among persons who inject drugs at high risk of hepatitis C virus infection: room for improvement. J Viral Hepat. 2015 Oct;22(10):792-9.

Artenie AA, Roy É, Zang G, Jutras-Aswad D, Bamvita JM, et al. Hepatitis C Virus seroconversion among persons who inject drugs in relation to primary care physician visiting: The potential role of primary healthcare in a combined approach to Hepatitis C prevention. Int J Drug Policy. 2015 Oct;26(10):970-5.

Artenie AA, Bruneau J, Roy É, Zang G, Lespérance F, et al. Licit and illicit substance use among people who inject drugs and the association with subsequent suicidal attempt. Addiction. 2015 Oct;110(10):1636-43

Olmstead AD, Joy JB, Montoya V, Luo I, Poon AF, et al. A molecular phylogenetics-based approach for identifying recent hepatitis C virus transmission events. Infect Genet Evol. 2015 Jul;33:101-9.

Cunningham EB, Jacka B, DeBeck K, Applegate TL, Harrigan PR, et al. Methamphetamine injecting is associated with phylogenetic clustering of hepatitis C virus infection among street-involved youth in Vancouver, Canada. Drug Alcohol Depend. 2015 Jul 1;152:272-6.

Cunningham EB, Applegate TL, Lloyd AR, Dore GJ, Grebely J. Mixed HCV infection and reinfection in people who inject drugs--impact on therapy. Nat Rev Gastroenterol Hepatol. 2015 Apr;12(4):218-30.

Moqueet N, Infante-Rivard C, Platt RW, Young J, Cooper C, et al. Favourable IFNL3 genotypes are associated with spontaneous clearance and are differentially distributed in Aboriginals in Canadian HIV-hepatitis C co-infected individuals. Int J Mol Sci. 2015 Mar 20;16(3):6496-512.

Ji H, Kozak RA, Biondi MJ, Pilon R, Vallee D, et al. Next generation sequencing of the hepatitis C virus NS5B gene reveals potential novel S282 drug resistance mutations. Virology. 2015 Mar;477:1-9.

Artenie AA, Bruneau J, Zang G, Lespérance F, Renaud J, et al. Associations of substance use patterns with attempted suicide among persons who inject drugs: can distinct use patterns play a role?. Drug Alcohol Depend. 2015 Feb 1;147:208-14.

2014

Wong JA, Bhat R, Hockman D, Logan M, Chen C, et al. Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization. J Virol. 2014 Dec;88(24):14278-88.

Burles K, van Buuren N, Barry M. Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB. Virology. 2014 Nov;468-470:351-62.

Jacka B, Applegate T, Krajden M, Olmstead A, Harrigan PR, et al. Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada. Hepatology. 2014 Nov;60(5):1571-80.

Nasheri N, McKay CS, Fulton K, Twine S, Powdrill MH, et al. Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions. Chembiochem. 2014 Oct 13;15(15):2195-200.

Artenie AA, Bruneau J, Lévesque A, Wansuanganyi JM. Role of primary care providers in hepatitis C prevention and care: one step away from evidence-based practice. Can Fam Physician. 2014 Oct;60(10):881-2, e468-70.

Abdel-Hakeem MS, Bédard N, Murphy D, Bruneau J, Shoukry NH. Signatures of protective memory immune responses during hepatitis C virus reinfection. Gastroenterology. 2014 Oct;147(4):870-881.e8.

MacParland SA, Bilodeau M, Grebely J, Bruneau J, Cooper C, et al. The 3rd Canadian Symposium on Hepatitis C Virus: expanding care in the interferon-free era. Can J Gastroenterol Hepatol. 2014 Oct;28(9):481-7.

van Buuren N, Burles K, Schriewer J, Mehta N, Parker S, et al. EVM005: an ectromelia-encoded protein with dual roles in NF-κB inhibition and virulence. PLoS Pathog. 2014 Aug;10(8):e1004326.

Atoom AM, Taylor NG, Russell RS. The elusive function of the hepatitis C virus p7 protein. Virology. 2014 Aug;462-463:377-87.

Singaravelu R, Delcorde J, Lyn RK, Steenbergen RH, Jones DM, et al. Investigating the antiviral role of cell death-inducing DFF45-like effector B in HCV replication. FEBS J. 2014 Aug;281(16):3751-65.

Sherratt AR, Nasheri N, McKay CS, O'Hara S, Hunt A, et al. A new chemical probe for phosphatidylinositol kinase activity. Chembiochem. 2014 Jun 16;15(9):1253-6.

Karam P, Powdrill MH, Liu HW, Vasquez C, Mah W, et al. Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA. J Biol Chem. 2014 May 16;289(20):14399-411.

Lyn RK, Singaravelu R, Kargman S, O'Hara S, Chan H, et al. Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes. Sci Rep. 2014 Apr 1;4:4549

Holder KA, Russell RS, Grant MD. Natural killer cell function and dysfunction in hepatitis C virus infection. Biomed Res Int. 2014;2014:903764.

Bamvita JM, Roy E, Zang G, Jutras-Aswad D, Artenie AA, et al. Portraying persons who inject drugs recently infected with hepatitis C accessing antiviral treatment: a cluster analysis. Hepat Res Treat. 2014;2014:631481. [PubMed] Abdel-Hakeem MS, Shoukry NH. Protective immunity against hepatitis C: many shades of gray. Front Immunol. 2014;5:274.

Abdel-Hakeem MS, Shoukry NH. Protective immunity against hepatitis C: many shades of gray. Front Immunol. 2014 Jun 16;5:274.

Singaravelu R, Chen R, Lyn RK, Jones DM, O'Hara S, et al. Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis. Hepatology. 2014 Jan;59(1):98-108.

2013

Steenbergen RH, Joyce MA, Thomas BS, Jones D, Law J, et al. Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers. Hepatology. 2013 Dec;58(6):1907-17.

Grebely J, Bilodeau M, Feld JJ, Bruneau J, Fischer B, et al. The Second Canadian Symposium on hepatitis C virus: a call to action. Can J Gastroenterol. 2013 Nov;27(11):627-32

Holder KA, Stapleton SN, Gallant ME, Russell RS, Grant MD. Hepatitis C virus-infected cells downregulate NKp30 and inhibit ex vivo NK cell functions. J Immunol. 2013 Sep 15;191(6):3308-18.

Thibault PA, Wilson JA. Targeting miRNAs to treat Hepatitis C Virus infections and liver pathology: Inhibiting the virus and altering the host. Pharmacol Res. 2013 Sep; 75:48-59. PMID: 23541631.

Atoom AM, Jones DM, Russell RS. Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production. Virus Res. 2013 Sep;176(1-2):199-210.

Sagan SM, Sarnow P, Wilson JA. Modulation of GB virus B RNA abundance by microRNA-122: dependence on and escape from microRNA-122 restriction. J Virol. 2013 Jul;87(13):7338-47.

Pelletier S, Bédard N, Said E, Ancuta P, Bruneau J, et al. Sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C. J Virol. 2013 Jun;87(12):6769-81.

Deans GD, Raffa JD, Lai C, Fischer B, Krajden M, et al. Mortality in a large community-based cohort of inner-city residents in Vancouver, Canada. CMAJ Open. 2013 May; 1(2):E68-76.

Nasheri N, Joyce M, Rouleau Y, Yang P, Yao S, et al. Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication. Chem Biol. 2013 Apr 18;20(4):570-82.

Thibault PA, Huys A, Dhillon P, Wilson JA. MicroRNA-122-dependent and -independent replication of Hepatitis C Virus in Hep3B human hepatoma cells. Virology. 2013 Feb 5;436(1):179-90.

Law JL, Chen C, Wong J, Hockman D, Santer DM, et al. A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans. PLoS One. 2013;8(3):e59776.

Huys A, Thibault PA, Wilson JA. Modulation of hepatitis C virus RNA accumulation and translation by DDX6 and miR-122 are mediated by separate mechanisms. PLoS One. 2013;8(6):e67437.

Mazumder N, Lyn RK, Singaravelu R, Ridsdale A, Moffatt DJ, et al. Fluorescence lifetime imaging of alterations to cellular metabolism by domain 2 of the hepatitis C virus core protein. PLoS One. 2013;8(6):e66738.

Sarhan MA, Chen AY, Michalak TI. Differential expression of candidate virus receptors in human T lymphocytes prone or resistant to infection with patient-derived hepatitis C virus. PLoS One. 2013;8(4):e62159

Nasheri N, Pezacki JP, Sagan SM. Design and screening of siRNAs against highly structured RNA targets. Methods Mol Biol. 2013;942:69-86.

Weaver A, Menard D, Cabrera C, Taylor A. Embodying the moral code: Thirty years of final girls in slasher films. Psychology of Popular Media Culture. 2013.

2012

Machlin ES, Sarnow P, Sagan SM. Combating hepatitis C virus by targeting microRNA-122 using locked nucleic acids. Curr Gene Ther. 2012 Aug;12(4):301-6.

Singaravelu R, Nasheri N, Sherratt A, Pezacki JP. Systems biology methods help develop a better understanding of hepatitis C virus-induced liver injury. Hepatology. 2012 Jul;56(1):1-4.

Sarhan MA, Pham TN, Chen AY, Michalak TI. Hepatitis C virus infection of human T lymphocytes is mediated by CD5. J Virol. 2012 Apr;86(7):3723-35.

Blais DR, Nasheri N, McKay CS, Legault MC, Pezacki JP. Activity-based protein profiling of host-virus interactions. Trends Biotechnol. 2012 Feb;30(2):89-99.

Beq S, Rozlan S, Pelletier S, Willems B, Bruneau J, et al. Altered thymic function during interferon therapy in HCV-infected patients. PLoS One. 2012;7(4):e34326.

Kneteman NM, Asthana S, Lewis J, Dibben C, Douglas D, et al. Impact of calcineurin inhibitors with or without interferon on hepatitis C virus titers in a chimeric mouse model of hepatitis C virus infection. Liver Transpl. 2012 Jan;18(1):38-44.

Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, et al. Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection. PLoS One. 2012;7(7):e40146.

Cabrera C, & Menard AD. She exploded into a million pieces: A multi-method examination of orgasm descriptions in contemporary romance novels. Sexuality and Culture, 2012,16,4.

Zachariades F & Cabrera C. The duty to warn revisited: Contemporary issues in the North American context. Journal of Ethics in Mental Health, 2012, 7,1. Zachariades F & Cabrera C. The duty to warn revisited: Contemporary issues in the North American context. Journal of Ethics in Mental Health, 2012, 7,1.

Zhang C, Huys A, Thibault PA, Wilson JA. Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance. Virology. 2012 Nov 25;433(2):479-88.

Sarhan MA, Chen AY, Russell RS, Michalak TI. Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes. J Gen Virol. 2012 Nov;93(Pt 11):2399-407.

John-Baptiste A, Yeung MW, Leung V, van der Velde G, Krahn M. Cost effectiveness of hepatitis C-related interventions targeting substance users and other high-risk groups: a systematic review. Pharmacoeconomics. 2012 Nov 1;30(11):1015-34.

Pattullo V, Thein HH, Heathcote EJ, Guindi M. Combining semiquantitative measures of fibrosis and qualitative features of parenchymal remodelling to identify fibrosis regression in hepatitis C: a multiple biopsy study. Histopathology. 2012 Sep;61(3):473-87.

2011

Powdrill MH, Tchesnokov EP, Kozak RA, Russell RS, Martin R, et al. Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20509-13.

Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, et al. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7094-8

Jones DM, Atoom AM, Zhang X, Kottilil S, Russell RS. A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus. J Virol. 2011 Dec;85(23):12351-61

Shoukry NH, Pelletier S, Chang KM. A view to natural killer cells in hepatitis C. Gastroenterology. 2011 Oct;141(4):1144-8.

Cheng J, Danielson DC, Nasheri N, Singaravelu R, Pezacki JP. Enhanced specificity of the viral suppressor of RNA silencing protein p19 toward sequestering of human microRNA-122. Biochemistry. 2011 Sep 13;50(36):7745-55.

Berke JM, Vijgen L, Lachau-Durand S, Powdrill MH, Rawe S, et al. Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother. 2011 Aug;55(8):3812-20.

Nasheri N, Cheng J, Singaravelu R, Wu P, McDermott MT, et al. An enzyme-linked assay for the rapid quantification of microRNAs based on the viral suppressor of RNA silencing protein p19. Anal Biochem. 2011 May 15;412(2):165-72.

Lin LT, Chen TY, Chung CY, Noyce RS, Grindley TB, et al. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread. J Virol. 2011 May;85(9):4386-98.

Matthews GV, Pham ST, Hellard M, Grebely J, Zhang L, et al. Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C. Clin Infect Dis. 2011 Mar 15;52(6):803-11.

Pezacki JP, Blake JA, Danielson DC, Kennedy DC, Lyn RK, et al. Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat Chem Biol. 2011 Mar;7(3):137-45.

Machlin ES, Sarnow P, Sagan SM. Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3193-8

Nasheri N, Singaravelu R, Goodmurphy M, Lyn RK, Pezacki JP. Competing roles of microRNA-122 recognition elements in hepatitis C virus RNA. Virology. 2011 Feb 20;410(2):336-44.

Grebely J, Raffa JD, Lai C, Kerr T, Fischer B, et al. Impact of hepatitis C virus infection on all-cause and liver-related mortality in a large community-based cohort of inner city residents. J Viral Hepat. 2011 Jan;18(1):32-41.

Vali B, Tohn R, Cohen MJ, Sakhdari A, Sheth PM, et al. Characterization of cross-reactive CD8+ T-cell recognition of HLA-A2-restricted HIV-Gag (SLYNTVATL) and HCV-NS5b (ALYDVVSKL) epitopes in individuals infected with human immunodeficiency and hepatitis C viruses. J Virol. 2011 Jan;85(1):254-63

Menard, A.D. & Cabrera, C. Whatever the approach, Tab B still fits into slot A: Twenty years of sex scripts in romance novels. Sexuality and Culture, 2011, 15, 1. Menard, A.D. & Cabrera, C. Whatever the approach, Tab B still fits into slot A: Twenty years of sex scripts in romance novels. Sexuality and Culture, 2011, 15, 1.

MacParland SA, Vail B, and Ostrowski M. The immunopathogenesis of HIV/Hepatitis C virus coinfection. Future Virology 2011; 6, 1115-1128.

2010

Dore GJ, Hellard M, Matthews GV, Grebely J, Haber PS, et al. Effective treatment of injecting drug users with recently acquired hepatitis C virus infection. Gastroenterology. 2010 Jan;138(1):123-35.e1-2.

Liao PC, Ng LT, Lin LT, Richardson CD, Wang GH, et al. Resveratrol arrests cell cycle and induces apoptosis in human hepatocellular carcinoma Huh-7 cells. J Med Food. 2010 Dec;13(6):1415-23.

Grebely J, Matthews GV, Petoumenos K, Dore GJ. Spontaneous clearance and the beneficial impact of treatment on clearance during recent hepatitis C virus infection. J Viral Hepat. 2010 Dec;17(12):896.

Ma XZ, Bartczak A, Zhang J, Khattar R, Chen L, et al. Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome. J Virol. 2010 Dec;84(23):12419-28.

Pelletier S, Drouin C, Bédard N, Khakoo SI, Bruneau J, et al. Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses. J Hepatol. 2010 Nov;53(5):805-16.

Powdrill MH, Bernatchez JA, Götte M. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses. 2010 Oct;2(10):2169-95.

Grebely J, Petoumenos K, Hellard M, Matthews GV, Suppiah V, et al. Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology. 2010 Oct;52(4):1216-24.

Steenbergen RH, Joyce MA, Lund G, Lewis J, Chen R, et al. Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success. Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G844-54

Abdel-Hakeem MS, Bédard N, Badr G, Ostrowski M, Sékaly RP, et al. Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus. J Virol. 2010 Oct;84(19):10429-35.

Vivithanaporn P, Maingat F, Lin LT, Na H, Richardson CD, et al. Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity. PLoS One. 2010 Sep 21;5(9):e12856.

Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, et al. HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur J Immunol. 2010 Sep;40(9):2493-505.

Gujar SA, Jenkins AK, Macparland SA, Michalak TI. Pre-acute hepadnaviral infection is associated with activation-induced apoptotic death of lymphocytes in the woodchuck (Marmota monax) model of hepatitis B. Dev Comp Immunol. 2010 Sep;34(9):999-1008.

Lin LT, Noyce RS, Pham TN, Wilson JA, Sisson GR, et al. Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122. J Virol. 2010 Sep;84(18):9170-80.

Zhao L, Shields J, Tyrrell DL. Functional changes, increased apoptosis, and diminished nuclear factor-kappaB activity of myeloid dendritic cells during chronic hepatitis C infection. Hum Immunol. 2010 Aug;71(8):751-62.

Kawahara T, Toso C, Douglas DN, Nourbakhsh M, Lewis JT, et al. Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model. Liver Transpl. 2010 Aug;16(8):974-82.

John-Baptiste A, Krahn M, Heathcote J, Laporte A, Tomlinson G. The natural history of hepatitis C infection acquired through injection drug use: meta-analysis and meta-regression. J Hepatol. 2010 Aug;53(2):245-51.

Grebely J, Knight E, Ngai T, Genoway KA, Raffa JD, et al. Reinfection with hepatitis C virus following sustained virological response in injection drug users. J Gastroenterol Hepatol. 2010 Jul;25(7):1281-4.

Lin LT, Dawson PW, Richardson CD. Viral interactions with macroautophagy: a double-edged sword. Virology. 2010 Jun 20;402(1):1-10.

Sagan SM, Nasheri N, Luebbert C, Pezacki JP. The efficacy of siRNAs against hepatitis C virus is strongly influenced by structure and target site accessibility. Chem Biol. 2010 May 28; 17(5):515-27.

Sagan SM, Sarnow P. Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7625-6.

Powdrill MH, Deval J, Narjes F, De Francesco R, Götte M. Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines. Antimicrob Agents Chemother. 2010 Mar;54(3):977-83.

Grebely J, Knight E, Genoway KA, Viljoen M, Khara M, et al. Optimizing assessment and treatment for hepatitis C virus infection in illicit drug users: a novel model incorporating multidisciplinary care and peer support. Eur J Gastroenterol Hepatol. 2010 Mar;22(3):270-7.

Grebely J, Petoumenos K, Matthews GV, Haber P, Marks P, et al. Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study. Drug Alcohol Depend. 2010 Mar 1;107(2-3):244-9

Chen L, Borozan I, Sun J, Guindi M, Fischer S, et al. Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection. Gastroenterology. 2010 Mar;138(3):1123-33.e1-3.

Chen L, Sun J, Meng L, Heathcote J, Edwards AM, et al. ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment. J Gen Virol. 2010 Feb;91(Pt 2):382-8.

Mohajerani SA, Nourbakhsh M, Cadili A, Lakey JR, Kneteman NM. Transplant of Primary Human Hepatocytes Cocultured With Bone Marrow Stromal Cells to SCID Alb-uPA Mice. Cell Med. 2010;1(2):81-92.

2009

Godin-Ethier J, Pelletier S, Hanafi LA, Gannon PO, Forget MA, et al. Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance. J Immunol. 2009 Dec 15;183(12):7752-60.

Lyn RK, Kennedy DC, Sagan SM, Blais DR, Rouleau Y, et al. Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology. 2009 Nov 10;394(1):130-42.

Thein HH, Yi Q, Heathcote EJ, Krahn MD. Prognosis of hepatitis C virus-infected Canadian post-transfusion compensation claimant cohort. J Viral Hepat. 2009 Nov;16(11):802-13.

Selzner M, Selzner N, Chen L, Borozan I, Sun J, et al. Exaggerated up-regulation of tumor necrosis factor alpha-dependent apoptosis in the older mouse liver following reperfusion injury: targeting liver protective strategies to patient age. Liver Transpl. 2009 Nov;15(11):1594-604.

John-Baptiste AA, Tomlinson G, Hsu PC, Krajden M, Heathcote EJ, et al. Sustained responders have better quality of life and productivity compared with treatment failures long after antiviral therapy for hepatitis C. Am J Gastroenterol. 2009 Oct;104(10):2439-48.

Grebely J, Thomas DL, Dore GJ. HCV reinfection studies and the door to vaccine development. J Hepatol. 2009 Oct;51(4):628-31.

Chong CA, Li S, Nguyen GC, Sutton A, Levy MH, et al. Health-state utilities in a prisoner population: a cross-sectional survey. Health Qual Life Outcomes. 2009 Aug 28;7:78.

Cheng J, Koukiekolo R, Kieliszkiewicz K, Sagan SM, Pezacki JP. Cysteine residues of Carnation Italian Ringspot virus p19 suppressor of RNA silencing maintain global structural integrity and stability for siRNA binding. Biochim Biophys Acta. 2009 Aug;1794(8):1197-203.

Koukiekolo R, Jakubek ZJ, Cheng J, Sagan SM, Pezacki JP. Studies of a viral suppressor of RNA silencing p19-CFP fusion protein: a FRET-based probe for sensing double-stranded fluorophore tagged small RNAs. Biophys Chem. 2009 Aug;143(3):166-9.

John-Baptiste A, Varenbut M, Lingley M, Nedd-Roderique T, Teplin D, et al. Treatment of hepatitis C infection for current or former substance abusers in a community setting. J Viral Hepat. 2009 Aug;16(8):557-67.

Seaman K, Paterson BL, Vallis M, Hirsch G, Peltekian KM. Future directions for investigation of fatigue in chronic hepatitis C viral infection. Chronic Illn. 2009 Jun;5(2):115-28.

Welbourn S, Jirasko V, Breton V, Reiss S, Penin F, et al. Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly. J Gen Virol. 2009 May;90(Pt 5):1071-80.

MacParland SA, Pham TN, Guy CS, Michalak TI. Hepatitis C virus persisting after clinically apparent sustained virological response to antiviral therapy retains infectivity in vitro. Hepatology. 2009 May;49(5):1431-41.

Grebely J, Raffa JD, Lai C, Krajden M, Kerr T, et al. Low uptake of treatment for hepatitis C virus infection in a large community-based study of inner city residents. J Viral Hepat. 2009 May;16(5):352-8.

Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, Bélanger S, et al. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC Chem Biol. 2009 Jan 16;9:2.

Conway B, Grebely J, Tossonian H, Lefebvre D, de Vlaming S. A systematic approach to the treatment of HIV and hepatitis C virus infection in the inner city: a Canadian perspective. Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S73-8.

Cabrera C, Miller D. The value of grades in graduate school. Psynopsis, Canada’s Psychology Newspaper, 2009, 31(3), 29.

Cabrera C, Saciragic L, Ethier J. Student perspectives of the multidisciplinary experience. Psynopsis, Canada’s Psychology Newspaper, 2009, 31(1), 26.

Thein HH, Dore GJ. Health-related quality of life in prisoners. Preedy VR, Watson RR (eds.) (2009) Handbook of Disease Burdens and Quality of Life Measures. Springer, New York.

Welbourn S. and Pause A. The hepatitis C virus NS2/3 protease: A future antiviral drug target? Future Virology 4, 2009. pp. 463-472