University of Alberta
Basic Science
Virology, Chemistry

University of Alberta
KATZ Bldg, Rm. 6-142G
Edmonton, Alberta T6G 2H7
Canada
 

(780) 492-6265
(780) 492-3383

Department of Biochemistry and
Department of Medical Microbiology and Immunology
Li Ka Shing Institute of Virology

Luis M. Schang earned his veterinary degree from the University of Buenos Aires, Argentina. He moved to the USA in June 1991, to pursue a Ph.D. in the Department of Veterinary and Biomedical Sciences of the University of Nebraska-Lincoln. He defended his Ph.D. in December 1995, and moved to the University of Pennsylvania in August 1996 to work with the late Dr. P.A. Schaffer on the roles of cellular protein kinases in replication and gene expression of herpes simplex viruses 1 and 2 (HSV-1, HSV-2). He moved to Edmonton, Alberta, Canada, in November 2000 to take an Assistant Professor position in the Department of Biochemistry at the University of Alberta. He was promoted to Associate Professor in 2005 and to Full Professor in 2012. He is cross-appointed to the Department of Medical Microbiology and Immunology since 2001 and is a founding member of the Li Ka Shing Institute of Virology.

Dr. Schang research is centered on using chemical biology, molecular, virological, biophysical, and advanced imaging techniques to explore the roles of cellular factors on viral replication and pathogenesis. His is particularly interested in HCV entry and innovative approaches to antivirals. Dr. Schang discovered the effects of small molecule inhibitors of cellular CDKs (called PCIs) on viral gene expression. He was one of the first strong supporters of cellular proteins as targets for antiviral drugs. More recently, Dr. Schang’s group discovered the RAFIs, novel inhibitors of the infectivity of enveloped viruses, including influenza virus, hepatitis C virus and herpesviruses, which act on virion envelope lipids to prevent the formation of the negative curvature required for fusion to cellular membranes. With his group, they have also characterized the mechanism of action of natural products active against HCV. His research is published in the most prestigious journals in virology and antivirals, and in journals of general scientific interest.

Dr. Schang has trained or is training 17 Ph.D. and Master’s, students and a number of undergraduate ones. Trainees in his lab have earned studentships from the CIHR, NSERC, AI-HS and international granting agencies. Former trainees in his group have moved on to Professor, Medical Doctor, Pharmacists or senior policymaking positions. He has been or is in the graduate studies supervisory committees of 41 students and the examining committees of other 36. Dr. Schang teaches undergraduate, graduate and Medical students. He is the Chair of the Special Training in Research program for Medical Students.

Dr. Schang is a member of the International Society for Antiviral Research, and a member of the Publications Committee of the society. He was the co-chair of the International Herpesvirus Workshop, and is a member of the local organizing committee for the 2014 International Symposium on HCV and related viruses.

Dr. Schang’s research is funded by the Burroughs Wellcome Fund (BWF), and the Canadian Institute of Health Research (CIHR) among other sources. He is member of several editorial boards and grant review panels, in Canada, the USA, Asia and South America. He has received numerous awards for his research, teaching, and efforts in support of appropriate animal research ensuring the well being of the animals.